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Shikimic Acid Fermentation

In the Name of God

Biotechnology MSc. Seminar:

Current issues in production of Shikimic Acid, intermediate for the production of Oseltamivir, the Avian Flu drug

Supervised by:

Dr. Reza Yegani
Dr. Mohammad Hossein Sarrafzadeh
Mr. Habibollah Ramezanzade

by:
Kaveh Yazdifard

Presented on:
1385/10/3

Contents
Acknowledgement
Introduction
Shikimic Acid & its Natural Properties
Derivatives of Shikimic Acid

Avian Flu Sickness, Medications
Oseltamivir and Shikimic Acid's Role in Synthesis

Production of Shikimic Acid
Extracting Shikimic Acid from the Plant
Chemical Synthesis of Shikimic Acid
Biosynthesis & Shikimic Acid Pathway
Fermentation of Shikimic Acid using Microorganisms
Contrasting Production Methods & Advantages of Fermentative method

Investigating Appropriate Strains
Results & Future Aspects of Shikimic Acid Fermentation
References

Acknowledgement

The achieved results in this seminar and the upcoming relevant project are owing to undeniable helps and support of Zakaria Pharmaceutical Co.'s CEO Mr. Ramezanzadeh & my colleagues in R&D sector, mainly the R&D director Dr. Jassouri.
In clarifying my viewpoints on the project and on making a better literature work for the present seminar I strongly benefited from the helps of Dr. Sarrafzadeh and Dr. Yegani, to whom I shall always be grateful.

Introduction

The present seminar is a brief overview of the theoretical studies, toward implementing the industrial bioproduction plant in Zakaria Pharmaceuticals Co. The whole executive results will soon be handed over as the fellow student's MSc. Project.

Shikimic Acid & its Natural Properties


(3R, 4S, 5R)- (−)-3, 4, 5-Trihydroxy-1-cyclohexenecarboxylic acid

Shikimic acid, more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms. Its name comes from the Japanese flower...