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An Outline of the General Scentific Insights that Microbial Genome Sequencing
Can and Has Provided. An Outline of the General Scentific ...
Submitted by isleepinabed on May 18, 2008
Category: Science
Words: 2650 | Pages: 11
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An Outline of the General Scentific Insights that Microbial Genome Sequencing Can and Has Provided
Microbial genome sequencing may be first dated back to the work of Frederick Sanger, who in 1975 developed the “chain termination method”, or Dideoxy termination method; the first discovered method of complete DNA sequencing.1,2. Since then, sequencing techniques have improved greatly in their efficiency, although it took 20 years for the first entire genome to be sequenced, that of Haemophilis Influenzae, by Fleischmann et al3. To date there are nearly 400 complete prokaryote genome sequences publicly available4, and there are currently hundreds of more projects in motion. Genome sequencing has expanded and become a primary target for modern scientific research since the major breakthroughs of Frederick Sanger and Fleischmann et al, but to what avail? The purpose of this review is to determine how useful the knowledge of entire microbial genomes has proved to be to modern science, as well as the future possibilities and practical potential that this line of research has.
Various predictions have been made concerning the future potential of ascertaining entire microbial genomes; the United States Department of Energy has a publicly accessible website where information on potential microbial applications may be found5. A selection of these applications includes; “Cleanup of toxic-waste sites worldwide.”, “Production of novel therapeutic and preventative agents and pathways” and “Energy generation and development of renewable energy sources”, as well as numerous other considerable economic and environmental benefits.
Another proposed application of improved microbial genomics is targeted more specifically at rumen microbial genomics; the concept of overcoming certain rate limiting factors that affect fibre degradation6. It is hypothesised that the ascertaining of rumen micro-organism genome...
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