OPPapers.com Essay Index >> Science >> Malignant Hyperthermia
We have many free term papers and essays on Malignant Hyperthermia. We also have a wide variety of research papers and book reports available to you for free. You can browse our collection of term papers or use our search engine.
Malignant Hyperthermia Kay 1 Amy Kay Professor Robinson Medical Terminology October 12, 2005 Malignant Hyperthermia Malignant Hyperthermia (MH) is a pharmacogenetic
Neuroleptic Malignant Syndrome is a rare neurological disorder that is basically an adverse reaction to a neuroleptic or anti-psychotic drug. (5) It is commonly classified
movements, tremors, reduced appetite, kidney failure, heart attack, stroke, seizure, and malignant hyperthermia (increase in body temperature).
conflict with medical conditions Prevent medication conflict with family history (ex: Malignant Hyperthermia.) Clinical Guidelines Allow me to treat patients according
neurotoxic. In addition, in high doses it can cause a sharp increase in body temperature (malignant hyperthermia) leading to muscle breakdown and kidney and cardiovascular
Submitted by aek4375 on October 28, 2005
Category: Science
Words: 5661 | Pages: 23
Views: 390
Popularity Rank: 31,434
Average Member Grade: N/A (Add a Comment / Grade this Paper)
Kay 1
You must Login to view the entire paper.
Amy Kay
Professor Robinson
Medical Terminology
October 12, 2005
Malignant Hyperthermia
Malignant Hyperthermia (MH) is a pharmacogenetic disease of skeletal muscle. Characteristically patients with this disease have no signs or symptoms except during an anesthetic. When exposed to inhalational anesthetics (those which are gases), muscle metabolism increases, and a series of signs and symptoms appear, which if left untreated can lead to death. The earliest findings are an increased production of carbon dioxide and signs of increases sympathetic nervous system activity.
Malignant Hyperthermia is typically a life threatening disease, also referred to as a syndrome, which occurs when a person with Malignant Hyperthermia susceptibility trait is exposed to triggering factors, which include most inhalational anesthetics (though not Nitrous Oxide), succinylcholine ( a muscle relaxant used during surgery) and rarely stress. Classic Malignant Hyperthermia is characterized by hypermetabolism, (increased oxygen consumption and increased carbon dioxide production) muscle rigidity, muscle injury, and increased sympathetic nervous system activity. Hypermetabolism reflected by elevated carbon dioxide
Kay 2
production precedes the increase in body temperature. (http://www.mhaus.org)
In muscle contraction calcium is released into the cell as a key component in muscle contraction. In MH there is a problem with calcium reuptake. Intracellular calcium increases up 500 fold leading to substained muscle contraction. The cell incurs a severe oxygen debt, the constant demand for ATP leads to glycolysis and subsequent to lactic acidosis. Eventually this lead to membrane instability, cell rupture and rhabdomyolysis. (http://www.mhaus.org)
If you are not a member yet, Sign Up for free!