Importance of Steriochemistry
ASSIGNMENT ON
PHARMACEUTICAL IMPORTANCE OF STEREOCHEMISTRY
PREPARED FOR: Nowshin Nowaz Rumzhum Lecturer, Dept. of pharmacy Stamford University Bangladesh
PREPARED BY: Md. Wahid Rezwan ID No: BPH02805674 Batch No: 28th D
STAMFORD UNIVERSITY BANGLADESH
Introduction: Stereochemistry may seem like a trivial subject because differences between stereoisomers are usually subtle. In nature, however, and most importantly, in biological systems such as the human body, these subtle differences have sweeping implications. Most drugs for example, are often composed of a single stereoisomer of a compound, and while one stereoisomer may have positive effects on the body, another stereoisomer may be toxic. Because of this, a great deal of work done by synthetic organic chemists today is in devising methods to synthesize compounds that are purely one stereoisomer.Accordingly, examples of bioequivalence studies based on stereospecific assays have started to appear in the literature. Fortunately, facile stereospecific assays have become available in the last several years for many drugs. Consequently, regulatory agencies have started to take the issue of stereochemistry into consideration in the assessment of bioequivalence, particularly from the standpoint of generic substitution. Amino acids, Lactic acid and Carbohydrates are discussed with reference to their configurations. The importance of the different properties in isomeric forms of some common pharmaceuticals are also examined
1. The importance of stereochemistry in drug action is well-known. Different stereoisomers can have very different biological effects. This section builds on the study of stereochemistry in H2 Chemistry.
2.Learning Outcomes Candidates should be able to:
(a) explain the importance of optical isomerism to drug
PHARMACEUTICAL IMPORTANCE OF STEREOCHEMISTRY
PREPARED FOR: Nowshin Nowaz Rumzhum Lecturer, Dept. of pharmacy Stamford University Bangladesh
PREPARED BY: Md. Wahid Rezwan ID No: BPH02805674 Batch No: 28th D
STAMFORD UNIVERSITY BANGLADESH
Introduction: Stereochemistry may seem like a trivial subject because differences between stereoisomers are usually subtle. In nature, however, and most importantly, in biological systems such as the human body, these subtle differences have sweeping implications. Most drugs for example, are often composed of a single stereoisomer of a compound, and while one stereoisomer may have positive effects on the body, another stereoisomer may be toxic. Because of this, a great deal of work done by synthetic organic chemists today is in devising methods to synthesize compounds that are purely one stereoisomer.Accordingly, examples of bioequivalence studies based on stereospecific assays have started to appear in the literature. Fortunately, facile stereospecific assays have become available in the last several years for many drugs. Consequently, regulatory agencies have started to take the issue of stereochemistry into consideration in the assessment of bioequivalence, particularly from the standpoint of generic substitution. Amino acids, Lactic acid and Carbohydrates are discussed with reference to their configurations. The importance of the different properties in isomeric forms of some common pharmaceuticals are also examined
1. The importance of stereochemistry in drug action is well-known. Different stereoisomers can have very different biological effects. This section builds on the study of stereochemistry in H2 Chemistry.
2.Learning Outcomes Candidates should be able to:
(a) explain the importance of optical isomerism to drug