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Hemoglobin

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Hemoglobin
(Raven, 2012)

BIOCHEMISTRY: Protein Function–Myoglobin and Hemoglobin by A. Scheider
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Tuesday, March 12, 13

Alpha helix polypeptide chains

Heme complex with Oxygen attached to iron Heme complex without Oxygen attached to iron

Beta sheet polypeptide chains

Model of Hemoglobin Molecule
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Tuesday, March 12, 13

Hemoglobin: quick facts
Hemoglobin is a protein that carries Oxygen and releases Oxygen to the body via the blood circulation. Hemoglobin is made of 4 polypeptide chains with each chain containing an iron-heme structure that contains the oxygen-binding site. Each hemoglobin molecule twists a polypeptide chain into a helical secondary structure. The helices drape around the heme group and form into a tertiary structure subunit. The four subunits are packed into a globular quaternary protein structure. The iron-heme structures give the red color to hemoglobin. Each hemoglobin molecule can carry and/or release a maximum of 4 oxygen molecules. The oxygen is picked up in the lungs and delivered to tissues as neede.d

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Oxygenated and Deoxygenated states of Hemoglobin (Hgb)
A molecule of hemoglobin loaded with oxygen is referred to as oxyhemoglobin. Oxyhemoglobin is an unstable protein that easily reverses its’ oxygen attachments. When a molecule of hemoglobin is empty of oxygen attachments, it is called deoxyhemoglobin. Portions of the terminal end of the amino acids in the deoxyhemoglobin will work together to form ionic pairs.
Tuesday, March 12, 13

These ionic pairs decrease the acidity of the blood by binding one hydrogen atom for every 2 oxygen molecules released. The resulting lowering of blood pH will trigger the intake of more oxygen. Deoxyhemoglobin presents in a bluish red color in the blood while oxyhemoglobin is bright red.

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(Childs, 2012)

Myoglobin vs Hemoglobin
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Tuesday, March 12, 13

Heme= Fe-protoporphyrin IX C34H32FeN4O4
Both Myoglobin and Hemoglobin contain the HEME complex


References: Bohr effect. (2012, August 18). In Wikipedia, The Free Encyclopedia. Retrieved 19:12, September 2, 2012, from http:// en.wikipedia.org/w/index.php?title=Bohr_effect&oldid=507961001 Casiday, R., & Frey, R. (2008, September 05). Hemoglobin and the heme group: metal complexes in the blood for oxygen transport . Retrieved from http://www.chemistry.wustl.edu/~edudev/LabTutorials/Hemoglobin/ MetalComplexinBlood.html Chemistry explained. (2012). Retrieved from http://www.chemistryexplained.com/Ge-Hy/Hemoglobin.html Childs, P. (2012, August 10). Haemoglobin - a molecular lung: 1. Retrieved from http://www3.ul.ie/~childsp/CinA/ Issue64/TOC36_Haemoglobin.htm Flegler, S. (Photographer). (2012). Normal red blood cell and a sickle cell. [Web Graphic]. Retrieved from http:// www.sciencephoto.com/media/116161/enlarge Hematology and blood disorders - sickle cell disease. (n.d.). Retrieved August 21, 2012 from http:// www.hopkinsmedicine.org/healthlibrary/conditions/hematology_and_blood_disorders/sickle_cell_disease_85,P00101/ Hemoglobin. (2012, August 14). In Wikipedia, The Free Encyclopedia. Retrieved 23:19, August 19, 2012, from http:// en.wikipedia.org/w/index.php?title=Hemoglobin&oldid=507456480 17 Tuesday, March 12, 13 Meyertholen , E. (n.d.). Hemoglobin/oxygen binding. Retrieved from http://www.austincc.edu/~emeyerth/ hemoglob.htm Mortada, I. (2009). the blood part 3, erythrocytes production . Retrieved from http://www.bio.miami.edu/~cmallery/150/ chemistry/hemoglobin.jpg Myoglobin. (2012, July 8). In Wikipedia, The Free Encyclopedia. Retrieved 23:17, August 19, 2012, from http:// en.wikipedia.org/w/index.php?title=Myoglobin&oldid=501230538 Prahl, S. (1998, June 08). Structure of heme. Retrieved from http://omlc.ogi.edu/spectra/hemoglobin/hemestruct/ index.html Sickle cell anemia: Blood video questions and translation practice worksheet. (2000, october 19). Retrieved from http:// chroma.gs.washington.edu/outreach/genetics/sickle/worksheet.html Sugimoto, H. et al. (2007, november 01). X-ray structure and reaction mechanism of human indoleamine 2,3dioxygenase. Retrieved from http://ars.els-cdn.com/content/image/1-s2.0-S0531513107004566-gr7.jpg The molecular biology of sickle cell anemia . (2003). Manuscript submitted for publication, Biology, Washington University, St. Louis, Available from Natural Sciences Learning Center . (1dzNN8XE9m4J)Retrieved from http:// www.nslc.wustl.edu/sicklecell/part2/molecular.html Vsrs, (2012). Chemical structure of hemoglobin in human blood. Viewed and retreived from http://www.drvsrs.com/ innovation.htm What is sickle cell anemia?. (2011, february 01). Retrieved from http://www.nhlbi.nih.gov/health/health-topics/topics/sca/ 18 Tuesday, March 12, 13
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