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Glycolysis

Submitted by tonnychopper on November 14, 2005

Category: Science
Words: 1550 | Pages: 7
Views: 176
Popularity Rank: 60,244
Average Member Grade: N/A (Add a Comment / Grade this Paper)

Cellular respiration is the process in which the chemical bonds of energy-rich molecules such as glucose are converted into energy usable for life processes. Oxidation of organic material¡ªin a bonfire, for example¡ªis an exothermic reaction that releases a large amount of energy rather quickly. The equation for the oxidation of glucose is:

C6H12O6 + 6O2 ¡ú 6CO2 + 6H2O + Energy released
Glycolysis is a metabolic pathway that is found in all living organisms and does not require oxygen. The process converts one molecule of glucose into two molecules of pyruvate, and makes energy in the form of two molecules of ATP. Glycolysis takes place in the cytoplasm of the cell. The overall reaction can be expressed this way:

Glucose + 2 NAD+ + 2 ATP + 2 Pi ¡ú 2 NADH + 2 pyruvate + 4 ATP + 2 H2O + 4 H+
The individual steps of the conversion of glucose into pyruvate are (in brief):

A glucose molecule from the hydrolysis of starch or glycogen is phosphorylated using one ATP molecule to give glucose-6-phosphate.
The glucose-6-phosphate is converted to fructose-6-phosphate by isomerisation.
Fructose-6-phosphate is again phosphorylated to give fructose-1,6-diphosphate with the use of another ATP molecule.
Next, the fructose-1,6-diphosphate is then lysed into two molecules of 3-carbon sugar (dihydroxyacetone phosphate and glyceraldehyde-3-phosphate) which are interconvertible.
The 3-carbon sugars are dehydrogenated and inorganic phosphate is added to them, forming two molecules of 1,3 diphosphoglycerate.
The hydrogen is used to reduce two molecules of NAD, a hydrogen carrier, to give NADH+H+. NADH+H+ later proceeds to the mitochondria for use in the electron transport chain.
The two molecules of 1,3 diphosphoglycerate lose two phosphate groups to form two molecules of glycerate-3-phosphate (3-phosphoglycerate), converting two molecules of ADP to ATP.
The two...

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