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Drug Study

Generic Name: Promethazine

Brand Name: Antinaus, Histanil, Pentazine, Phenadoz,
Phenergan, Promacot, Promet, Prorex

Classification:Therapeutic: antiemetics,antihistamines.
Sedatives/hypnotics
Pharmacologic: Phenothiazines

Suggested dose:

Antihistamine
← PO(adults) : 25 mg at bedtime or 10 – 12.5 mg 4 times daily.
← PO(children) : 5 – 12.5 mg 3 times a daily or 25 mg at bedtime
← IM, IV, Rect(adults) : 25 mg; may repeat in 2 hour.
← Rect(Children(2 year) : 0.125 mg/kg (3.75 mg/m2) q 4-6 hours or 0.5 mg/kg (15mg/m2) at bedtime; may also be given as 6.25 – 12.5 mg 3 times daily or 25 mg at bedtime.

Antivertigo (Motio Sickness)
← PO (adults) : 25 mg 30 -60 min before departure; may be repeated in 8 – 12 hr.
← PO (children) : 10 – 25 mg or 0.5mg/kg 30 – 60 min before departure; may be given twice daily.

Sedation
← PO, Rect, IM, IV (adults) : 20 – 50 mg
← PO, Rect, IM (children ( 2 yr) : 10 – 25 mg or 0.5 – 1.1 mg/kg

Sedation during labor
← IM, IV (Adults) : 50 mg in early labor; when labor is established, additional doses of 25 – 75 mg may be given 1 – 2 times at 4 hours intervals. (24-hr dose should not exceed 100 mg)

Antiemetic
← PO, Rect, IM, IV(adults) : 10 – 25 mg q 4 hours as needed; initial PO dose should be 25 mg.
← PO, Rect, IM (children (2 yr) : 0.25 – 0.5 mg/kg (7.5 – 15 mg/m2) q 4 – 6 hours or 10 – 25 mg q 4 -6 hours.

Mode of action:

← Well absorbed after oral administration; rectal administration maybe less reliable.
← Blocks the effects of histamine. Has inhibitory effect on the chemoreceptor trigger zone in the medulla, resulting in antiemetic properties.
← Alters the effects of dopamine in the CNS.
← Possesses significant anticholinergenic activity.
← Produces CNS depression by indirectly decreased stimulation of...