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Current Therapies And Emerging Targets For The Treatment Of Diabetes

Current Therapies and Emerging Targets for the Treatment of Diabetes by Imran Vhora

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CURRENT THERAPIES AND EMERGING TARGETS FOR THE TREATMENT OF DIABETES

INDEX
Sr.No TITLE PAGE NO 4 1 Introduction 6 2 Insulin analogues or modified insulin / Improved delivery 2.1 Insulin mimetics OR insulin / modified insulin 6 2.2 Improved delivery vehicles 7 9 3 Enhancers of insulin release 3.1 Sulfonylureas 9 3.2 Glucagon Like Peptide-1(GLP-1) 9 3.3 Imidazolines 10 11 4 Inhibitors of Hepatic Glucose Production 4.1 Consideration Of Biological Regulation 11 4.2 Glucagon Receptor Antagonists 12 4.3 Biguanides-Metformin 12 4.4 Fructos1,6-bisphosphatase(FBPase) Inhibition 12 4.5 Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors 13 4.6 Glucose-6-Phosphatase(G-6-Pase) Inhibition 13 15 5 Enhancers Of Insulin Action 5.1 15 Ligands For Peroxisome Proliferator Activated Receptors γ (PPAR γ) 5.2 Thiazolidinediones(TZDs) 16 5.3 Non-Thiazolidinediones(Non-TZDs) 18 5.4 Rexinoids And Retinoids X Receptors(RXRs) 19 5.5 20 β3 Adrenergic Receptor(β3AR) Agonists 5.6 Protein Tyrosine Phosphatase-1B(PTP-1B) 20 5.7 Glycogen Synthase Kinase-3(GSK-3) 22 26 6 INHIBITORS OF GLUCOSE UPTAKE 6.1 Glycosidase Inhibitors 26 6.2 Inhibition of Gastric Emptying 26 6.3 Inhibition of Na+-Glucose Cotransporter (eg.SGLT) 27 29 7 AGENTS FOR THE TREATMENT OF DIABETIC COMPLICATIONS 7.1 Aldose Reductase Inhibitors (ARIs) 29 7.2 Advanced Glycation End-Products (AGE) 30

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CURRENT THERAPIES AND EMERGING TARGETS FOR THE TREATMENT OF DIABETES

Sr.No 7.3 7.4 7.5 7.6 8 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 9 9.1 9.2 9.3 9.4 9.5 9.6 10 11

TITLE Proinsulin C-peptide Protein Kinase C (PKC) Angiotensin II type 1 (AT1) Receptor Miscellaneous Antidiabetics GLP-1 as a Therapeutic Agent in Patients with Type 2 Diabetes Mellitus Introduction Synthesis, Distribution And Release Of GLP-1 Physiologic Actions Of GLP-1 GLP-1 And Type 2 Diabetes Exenatide Liraglutide CJC-1131 Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Current...