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Business Research Problem/Opportunity Analysis Posting ID: 83331 Business, Business Analysis Year 3 Business Research Problem/Opportunity Analysis Hi. This is a
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Current Business Research Project Paper The purpose of this paper is to analyze a scholarly research article in a professional journal and to provide a brief synopsis
Submitted by jlgray on March 15, 2007
Category: Business
Words: 1718 | Pages: 7
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Business Research Project
The mission and educational purpose of JAMA (Journal of American Medical Association) and the Archives Journals is to promote the science and art of medicine and the betterment of the public health. The purpose of the analysis or research for the psoriasis is to determine if within a population-based cohort psoriasis is an independent risk factor for myocardial infarction (MI) when controlling for major cardiovascular risk factors. Psoriasis is the most common T-helper cell type 1 (TH1) immunological disease. Evidence has linked TH1 diseases to myocardial infarction (MI). Psoriasis has been associated with cardiovascular diseases, but has only been investigated in hospital-based studies that did not control for major cardiovascular risk factors.
A prospective, population-based cohort study in the United Kingdom of patients with psoriasis aged 20 to 90 years, comparing outcomes among patients with and without a diagnosis of psoriasis. Data were collected by general practitioners as part of the patient's medical record and stored in the General Practice Research Database between 1987 and 2002, with a mean follow-up of 5.4 years. Adjustments were made for hypertension, diabetes, history of myocardial infarction, hyperlipidemia, age, sex, smoking, and body mass index. Patients with psoriasis were classified as severe if they ever received a systemic therapy. Up to 5 controls without psoriasis were randomly selected from the same practices and start dates as the patients with psoriasis. A total of 556 995 control patients and patients with mild (n = 127 139) and severe psoriasis (n = 3837) were identified.
There were 11 194 MIs (2.0%) within the control population and 2319 (1.8%) and 112 (2.9%) MIs within the mild and severe psoriasis groups, respectively. The incidences per 1000 person-years for control patients and patients with mild and severe psoriasis were 3.58 (95% confidence interval [CI],...
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